Clinical features and risk factors of intracranial hemorrhage in patients with cerebral venous sinus thrombosis
10.3760/cma.j.issn.1671-8925.2017.11.009
- VernacularTitle:脑静脉/静脉窦血栓形成患者易发脑出血的因素分析
- Author:
Jun SUN
1
;
Zhixin FU
Author Information
1. 473003,南阳市中心医院神经内科
- Keywords:
Cerebral venous/sinus thrombosis;
Intracranial hemorrhage;
Influencing factor
- From:
Chinese Journal of Neuromedicine
2017;16(11):1125-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features,pathogenic factors and sites of thrombus involvement in patients with cerebral venous/venous sinus thrombosis (CVST) complicated with cerebral hemorrhage.Methods Eighty-seven patients with CVST,admitted to our hospital from January 2013 to December 2016,were selected and divided into observation group (n=39) and control group (n=48) according to cerebral hemorrhage.The demographic data,clinical features,pathogenic factors,and location of the involved venous/venous sinus were compared and analyzed between the two groups.The independent influencing factors of CVST combined with intracerebral hemorrhage were assessed using multivariable Logistic regression.Results Percentages of patients with decreased visual acuity (35.9％),epileptic seizure (48.7％),motor/sensory disorders (46.2％),consciousness changes (25.6％) and aphasia (12.8％) of the observation group were significantly higher than those of the control group (12.5％,16.7％,18.8％,8.3％,and 0％,P＜0.05).In the aspect of potential pathogenic factors,the proportion of patients at pregnancy/puerperium in the observation group (20.6％) was significantly higher than that in the control group (6.3％,P＜0.05).In the aspect of involving venous/venous sinus area,the proportion of patients involved in straight sinus in the observation group (30.8％) was significantly higher than that in the control group (12.5％,P＜0.05).Multivariate Logistic analysis showed that pregnancy/puerperium and involvement of straight sinus were the independent influencing factors of CVST combined with cerebral hemorrhage (OR=6.752,P=0.017,95％CI:2.295-16.213;OR=4.573,P=0.029,95％CI:1.316-11.751).Conclusion CVST patients at pregnancy/postpartum or with straight sinus thrombosis are more prone to cerebral hemorrhage,and targeted treatment should be given as soon as possible.
