Correlation between silent information regulator 1 polymorphisms and intracerebral hemorrhage susceptibility in Han ethnic population of South China
10.3760/cma.j.issn.1671-8925.2017.11.002
- VernacularTitle:SIRT1基因多态性与中国南方汉族人群脑出血的相关性研究
- Author:
Xiehua XUE
1
;
Qingping SU
;
Wei WEI
;
Julian SHEN
;
Min XIA
;
Zhicheng LIN
Author Information
1. 350003福州,福建中医药大学附属康复医院神经康复科,福建省康复产业研究院
- Keywords:
Silent information regulator 1;
Intracerebral hemorrhage;
Single nucleotide polymophism
- From:
Chinese Journal of Neuromedicine
2017;16(11):1091-1097
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of silent information regulator 1 (SIRT1) polymorphisms with intracerebral hemorrhage (ICH) susceptibility.Methods From September 1,2013 to May 30,2017,Han ethnic 201 ICH patients and 203 controls from South China were enrolled in this study.Genotyping and sequencing ofSIRT1 polymorphisms (rs7069102,rs2273773 and rs7895833) were performed by PCR-restriction fragment length polymorphism (PCR-RFLP).The correlation of SIRT1 polymorphisms with ICH was analyzed.Results (1) The rs7895833 A allele frequency distribution was significantly higher and the rs7895833 GG+AG gene frequency distribution was significantly lower in the ICH group than those in the control group (P＜0.05);the rs7069102 C allele frequency distribution was lower and the GG+CG gene frequency distribution was higher in the ICH group than those in the control group,without significant differences (P＞0.05).(2) Logistic regression analysis indicated rs7895833 AA genotype carriers had increased risk for ICH (OR:1.57,95％CI:1.14-2.18,P=0.006).(3) As compared with patients with rs2273773 TT genotype,patients with CC and CT genotypes had significantly higher high-density lipoprotein cholesterol level (P＜0.05);there were no associations between rs2273773/rs7069102 and ICH.Conclusion SIRT1 rs7895833 is significantly associated with ICH susceptibility;rs2273773 genotypes affect plasma high-density lipoprotein cholesterol level in the Chinese Han ethnic population.
