Determination of serum fibroblast growth factor-22 level in patients with first episode depression and its related research
10.3760/cma.j.issn.1671-8925.2017.07.009
- VernacularTitle:首发抑郁症患者血清FGF-22水平测定及相关研究
- Author:
Yuhao XU
1
;
Ming YU
;
Yuefeng LI
;
Shun YAO
Author Information
1. 江苏大学附属医院神经内科
- Keywords:
First episode depression;
Fibroblast growth factor-22;
Hamilton's depression scale;
Serotonin;
Interleukin-1β
- From:
Chinese Journal of Neuromedicine
2017;16(7):697-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of serum fibroblast growth factor-22 (FGF-22) of first episode depressive patients before and after treatment,and its relations with serotonin (5-HT) and interleukin-1[β (IL-1β) levels and Hamilton's depression scale (HAMD) scores to provide assistance for further study of pathogenesis of depression.Methods Ninety patients with first episode depression accepted treatment in our hospital from June 2015 to June 2016 and 90 healthy controls were enrolled.The serum FGF-22 level was detected and Hamilton's depression scale (HAMD) was performed before and after drug treatment.The relations of FGF-22 level with 5-hydroxytryptamine (5-HT) and interleukin (IL)-1[β levels were analyzed.Results (1) Before treatment,the first episode depressive patients had significantly lower scrum FGF-22 level ([180.44±17.02] ng/mL) and statistically higher HAMD scores (17.84±5.92) as compared with the healthy controls ([200.74±16.63] ng/mL,1.88±2.67,P＜0.05).(2) The serum FGF-22 level after treatment ([195.74+19.57] ng/mL) was significantly higher than that before treatment,and the HAMD scores after treatment (7.64±4.09) were significantly lower than those before treatment (P＜0.05).(3) In the patient group,serum FGF-22 level and HAMD scores were negatively correlated (r=-0.644,P=0.000);serum FGF-22 level had positive correlation with 5-HT level (r=0.718,P=0.000),and negative correlation with IL-1β level (r=-0.763,P=0.000).Conclusion The serum FGF-22 level is abnormal in first episode depressive patients,and it could be a good indicator of peripheral blood in response to depression,which plays an important role in the pathogenesis of depression.
