Correlation between inducible nitric oxide synthase gene polymorphism and ischemic stroke in Uygur population of Xinjiang China
10.3760/cma.j.issn.1671-8925.2017.07.008
- VernacularTitle:诱导型一氧化氮合酶基因多态性和中国新疆地区维吾尔族人群缺血性脑卒中发病的关联性
- Author:
Yanwei ZHANG
1
;
Jingjun HAN
;
Zhixin CAO
;
Der KA
;
Jinquan CHENG
Author Information
1. 518055,深圳市疾病预防控制中心分子生物医学检验科
- Keywords:
Inducible nitric oxide synthase;
Ischemic stroke;
Genetic polymorphism;
Risk factor;
Uygur population
- From:
Chinese Journal of Neuromedicine
2017;16(7):692-696
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between inducible nitric oxide synthase (iNOS) gene polymorphisms and ischemic stroke in Uygur population of Xinjiang.Methods A case-control study was performed,included 316 patients with ischemic stroke,admitted to our hospital from June 2007 to December 2013,and 316 age-and gender-matched healthy subjects in Uygur population of Hami.The genotypes ofrs2779248(C/T) and rs1137933(C/T) were determined by Taqman probe fluorescent quantitative PCR.Results The distribution frequencies of rs2779248 (CC,CT and TT) were 51.9％,42.1％ and 6.0％ in the patient group,ands 61.7％,30.1％ and 8.2％ in the controls,respectively.As compared with those with rs2779248 CC genotype,individuals with CT+TT genotype and CT genotype had higher risk ofischemic stroke,the odds ratio was 1.49 (95％CI:1.09-2.05,P=0.013)and 1.66 (95％CI:1.19-2.32,P=0.003).The distribution frequencies ofrs1137933 (CC,CT and TT) were 66.8％,28.5％ and 4.7％ in the patient group,ands 66.8％,27.8％ and 5.4％ in the controls,respectively;no significant difference was noted between the patient group and controls in the distribution frequencies (P＞0.05).Multi-factor Logistic regression analysis indicated that mutation of genotype C＞T in rs2779248was the independent risk factor of ischemic stroke in Uygur population of Hami after adjusting related risk factors (OR=1.55,95％CI:1.00-2.40,P=0.049).Conclusion The polymorphisms ofrs2779248 in iNOS gene may modify the risk of ischemic stroke in Uygur population of Hami,but no association is found in rs1137933.
