Recent advance in role of acid sensing ion channels in process of epilepsy

VernacularTitle:酸敏感离子通道在癫痫发病中作用的研究进展
Author: Qian CAO ¹ ; Kang CHEN ; Zuneng LU ; Zheman XIAO
Author Information

1. 武汉大学人民医院神经内科
Keywords: Acid sensing ion channel; Epilepsy; Structure; Distribution
From: Chinese Journal of Neuromedicine 2017;16(4):339-343
CountryChina
Language:Chinese
Abstract: Acid sensing ion channels (ASICs) are voltage-independent,proton-gated,cation-selective channels composed of 6 different subunits which are encoded by 4 genes.These channels are sensitive to extracellular protons and open when the pH value decreases.Recently,accumulating evidences have suggested that activation of ASICs is involved in many physiological and pathological conditions associated with tissue acidification,including synaptic transmission,inflammation,ischemia,pain and epileptic seizures.Therefore,targeting these channels emerges as a potential promising therapeutic strategy to combat these diseases.This review will focus on the structure and distribution of ASICs,with special emphasis on their changes in the process of epilepsy,the influence they exert on seizure severity,as well as the possible mechanisms by which they modulate this disease.