Predictors of post-encephalitic epilepsy for patients with viral encephalitis at acute symptomatic seizures
10.3760/cma.j.issn.1671-8925.2017.04.003
- VernacularTitle:病毒性脑炎急性期痫性发作演变为脑炎后癫痫的因素分析
- Author:
Haiyan MA
1
;
Yanfang ZHANG
;
Qing DI
Author Information
1. 南京脑科医院癫痫科
- Keywords:
Vira encephalitis;
Epilepsy;
Risk factor
- From:
Chinese Journal of Neuromedicine
2017;16(4):334-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence ofpost-encephalitic epilepsy (PEE) and its influencing factors in patients with viral encephalitis at acute symptomatic seizures (AESS).Methods Seventy-six patients with AESS were collected in our hospital from June 2006 to June 2012.All patients were followed up for at least two years.PEE was defined as patients appearing at least one unprovoked seizure after acute periods of encephalitis and confirming by EEG.The PEE incidence of patients with AESS was observed.With Logistic regression,the factors affected patients with AESS to be PEE were explored.Results Twenty-nine patients developed into PEE among the 76 patients with AESS,with PEE incidence of 38.2％.Multiple Logistic regression analysis indicated that the status epilepticus during acute encephalitis was the independent predictor of PEE (OR=8.000,95％CI:1.890-33.950,P=0.005),and antiepileptic drugs after acute encephalitis was the protective factor of PEE (OR=0.330,95％CI:0.120-0.940,P=0.038).Conclusion PEE incidence of patients with AESS is high;status epilepticus during acute encephalitis is an independent risk factor for patients with AESS to be PEE,and these patients should continue take antiepileptic drugs after acute encephalitis.
