Molecular mechanisms of activated epidermal growth factor receptor signaling pathway mediating blood spinal cord barrier damage after spinal cord injury
10.3760/cma.j.issn.1671-8925.2017.01.020
- VernacularTitle:脊髓损伤后EGFR信号通路激活介导血脊髓屏障破坏机制的研究进展
- Author:
Xiaojun CAI
1
;
Huizhu SONG
;
Hao WEN
;
Shourong LU
;
Zaiwang LI
Author Information
1. 南京医科大学附属无锡市人民医院药学部
- Keywords:
Spinal cord injury;
Epidermal growth factor receptor;
Blood spinal cord barrier;
Microvascular endothelial cell;
Glial cell;
Molecular mechanism
- From:
Chinese Journal of Neuromedicine
2017;16(1):90-94
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury (SCI) is closely related to the breakdown of blood spinal cord barrier (BSCB).The epidermal growth factor receptor (EGFR) excessive activation plays a key role in the progression of BSCB and SCI destruction.We mainly reviewed the mechanism of EGFR signaling pathway activation in pathophysiology of BSCB damage after SCI.
