A comparative study of deglutition function of amyotrophic lateral sclerosis patients with or without diabetes mellitus type Ⅱ
10.3760/cma.j.issn.1671-8925.2016.12.013
- VernacularTitle:伴与不伴Ⅱ型糖尿病的肌萎缩侧索硬化患者吞咽功能的比较研究
- Author:
Zehua FANG
1
;
Yu ZHENG
;
Biying YANG
;
Zhijian ZHOU
;
Baoxin DU
Author Information
1. 广州中医药大学第二临床医学院
- Keywords:
Amyotrophic lateral sclerosis;
Diabetes mellitus type Ⅱ;
Dysphagia;
Videofluoroscopic swallow study
- From:
Chinese Journal of Neuromedicine
2016;15(12):1255-1259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between diabetes mellitus type Ⅱ (DM) and deglutition function of amyotrophic lateral sclerosis (ALS) patients.Methods Seventy-five ALS patients older than 45 years and admitted to our hospital from August 2008 to November 2015 were selected into this study;67 of them were without DM and 8 were with DM.Water swallow test,amyotrophic lateral sclerosis severity scale-swallow (s-ALSSS),amyotrophic lateral sclerosis functional rating scale (ALSFR-R) and videofluoroscopic swallow study (VFS) were performed to evaluate the deglutition functions of these ALS patients with or without DM,and the results of the two groups were compared.Results (1) Patients with DM had significantly higher s-ALSSS scores,ingurgitation part in ALSFRS-R scores and in parts of VFS scores,such as transportation to pharyngeal,pharyngeal transit,flow into pharyngeal before reflexion,epiglottic vallecula residue,and piriform sinus residue than patients without DM (8.88±1.34 vs.7.54±1.47,3.50±0.54 vs.2.96±0.77,2.88±0.35 vs.2.16±0.69,2.75±0.46 vs.2.09±0.69,2.88±0.35 vs.2.42±0.56,2.88±0.35 vs.2.39±0.58,P＜0.05).(2) Scores of Kubota drinking test,ALSFRS-R,VGF (including oral phase,pharyngeal phase and aspiration degree) in patients without DM were 2.15±1.12,7.18±1.41(1.78±0.69,1.69±0.60 and 3.72±0.65),and those in patients with DM were 1.88±1.34,8.00±0.93(2.13±0.64,2.00±0.53 and 4.00±0.00);no significant differences were noted between the two groups (P＞0.05),but there was a trend showing that DM patients had higher scores in these evaluations.Conclusion As compared with ALS patients without DM,ALS patients with DM get more mildly impaired deglutition function.
