Clinical features of adult male anti-N-methyl-D-aspartate receptor encephalitis
10.3760/cma.j.issn.1671-8925.2016.11.012
- VernacularTitle:成年男性抗N-甲基-D-天冬氨酸受体脑炎的临床特征分析
- Author:
Qing TIAN
1
;
Yu YANG
;
Jian BAO
;
Tingting LU
;
Zhengqi LU
Author Information
1. 中山大学附属第三医院神经内科
- Keywords:
Anti-NMDAR encephalitis;
Adult male;
Blood brain barrier;
Virus infection;
Demyelination
- From:
Chinese Journal of Neuromedicine
2016;15(11):1148-1153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the clinical features,ancillary tests,treatments and outcomes of adult male patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.Methods Observational study of clinical data,ancillary tests,treatments and outcomes of 5 adult male patients,admitted to our hospital from August 2014 to May 2016 and diagnosed as having anti-NMDAR encephalitis,was carried out.And the pathologic mechanism was discussed combining with literature review.Results All of the 5 adult male patients were not associated with treatoma,4 patients had significant relevant past medical histories,including purulent meningitis,drug abuse,colon descendens adenocarcinoma after radical resection and idiopathic inflammatory demyelinating disease (IIDD).For ancillary tests,positive virus antibodies were detected in two patients,and one of them presented positive EBV-DNA in CSF sample;one patient presented elevated thyroid autoantibodies in sera sample;four patients presented atypical abnormal brain contrast enhancement MRI,and three of them exhibited punctiform and/or patchy enhancement in brain parenchyma;one of them showed gliacyte proliferation after necrosis and another one presented demyelination.All patients had favorable outcomes after timely immune therapies.Conclusion Adult male patients who are rarely associated with teratomas may trigger by virus infection,other autoimmune or demyelinating diseases;the earlier application of immune therapies,the better the prognosis.
