Regulation of c-Jun signaling pathway in peripheral nerve demyelination
10.3760/cma.j.issn.1671-8925.2016.10.020
- VernacularTitle:c-Jun信号通路对周围神经脱髓鞘过程的调控研究进展
- Author:
Jiawei XU
1
;
Jinkun WEN
;
Yuchen LUO
;
Jiasong GUO
Author Information
1. 南方医科大学第一临床医学院
- Keywords:
c-Jun;
Peripheral nerve injury;
Demyelination;
Signaling pathway
- From:
Chinese Journal of Neuromedicine
2016;15(10):1071-1075
- CountryChina
- Language:Chinese
-
Abstract:
After peripheral nerve injury (PNI),myelinated Schwann cells undergo demyelination,dedifferentiation and proliferation,then migrate along basal lamina tubes and align to form the longitudinal cell strands known as bands of Btüngner,which creates suitable conditions for axonal regeneration and remyelination.By reviewing literature,we found that the expression of a transcriptional factor c-Jun increased during demyelination process after PNI,and increasing evidences suggested that demyelination and c-Jun signaling pathways were closely related.This review summarized the research situation and progress of c-Jim signaling pathways regulating demyelination process after peripheral nerve injury.
