Recent advance in mechanism of Toll-like receptor 2 in cerebral ischemic injury
10.3760/cma.j.issn.1671-8925.2016.09.018
- VernacularTitle:Toll样受体2在缺血性脑损伤中的作用机制研究进展
- Author:
Yun WEI
1
;
Qiang MENG
Author Information
1. 昆明理工大学医学院
- Keywords:
Ischemic brain injury;
Inflammation;
Toll-like receptor 2;
Myeloid differentiation primary response gene (88)
- From:
Chinese Journal of Neuromedicine
2016;15(9):955-960
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of cerebral ischemic injury is very complex.A lot of studies have shown that inflammatory reaction is one of the main mechanisms of cerebral ischemic injury,and the inflammatory response of the waterfall is more important.Experimental studies show that Toll like receptor 2 (TLR2) may play an important role in the initiation and development of cerebral ischemia,and may lead to the secondary brain injury.Myeloid differentiation factor 88 (MyD88) is the key of the TLR2 signal transduction pathway,which can activate the downstream inflammatory factors.And myd88 is mainly involved in the regulation of NF-κB DNA binding activity.The role of MyD88 signaling pathway mediated by TLR2 is reviewed in cerebral ischemic injury in this paper.MyD88 is the key link in the signal transduction pathway,which can be used as the research object of drug targeting therapy.
