Relationship between serum lipoprotein-associated phospholipase A2 and early neurological deterioration in patients with acute ischemic stroke
10.3760/cma.j.issn.1671-8925.2016.08.013
- VernacularTitle:血清脂蛋白相关磷脂酶A2与急性缺血性脑卒中早期神经功能恶化的相关性研究
- Author:
Yuanying SONG
1
;
Jianguo ZHONG
;
Peirong XIAO
;
Haicun SHI
Author Information
1. 224021,盐城市第三人民医院神经内科
- Keywords:
Acute ischemic stroke;
Early neurological deterioration;
Lipoprotein-associated phospholipase A2
- From:
Chinese Journal of Neuromedicine
2016;15(8):825-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the association between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and early neurological deterioration (END) in patients with acute ischemic stroke (AIS).Methods Two hundred and fifty-five AIS patients diagnosed by MR imaging were recruited between January 2011 and July 2015.The levels of serum Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) were assessed right after hospitalization.END was defined as any increase in National Institutes of Health Stroke Scale (NIHSS) scores ≥ 2 in the first 72 h after stroke onset,and the patients were accordingly divided into END group and non-END group.Risk factors associated with END and their clinical data were analyzed by Logistic regression analysis.Results END was observed in 72 of the 255 patients (28.23％).The percentage of female (58.3％ vs.31.3％),smoking ratio (58.3％ vs.31.3％),diabetes mellitus ratio (73.6％ vs.16.9％),prior stroke ratio (44.4％ vs.25.1％),NHISS scores (8 [3] vs.3 [2]),serum Lp-PLA2 level (230.31 ±75.57 μg/L vs.87.60±28.45 μg/L) and hs-CRP level (20.08±8.05 mg/L vs.6.73±3.48 mg/L) in the END group were significantly higher than those in the non-END group (P＜0.05).Multiple Logistic regression analyses indicated that END was positively associated with diabetes mellitus (OR=4.903,95％CI:1.363-17.695,P=0.015),Lp-PLA2 level (OR=1.032,95％CI:1.013-1.043,P=0.000) and hs-CRP level (OR=1.229,95％CI:1.087-1.391,P=0.001) in patients with acute ischemic stroke.Conclusion Serum Lp-PLA2 may predict END in Chinese patients with acute ischemic stroke.
