Recent advance in correlation between purinergic receptors and migraine
10.3760/cma.j.issn.1671-8925.2016.05.023
- VernacularTitle:嘌呤受体与偏头痛相关性的研究进展
- Author:
Renfang HAO
1
;
Jun ZHANG
Author Information
1. 遵义医学院附属医院神经内科
- Keywords:
Migraine;
Purinoceptor;
Cortical spreading depression;
Vasomotor mechanism
- From:
Chinese Journal of Neuromedicine
2016;15(5):529-532
- CountryChina
- Language:Chinese
-
Abstract:
Migraine is one of the common primary headaches in clinic,but the etiology and pathogenesis are still not fully understood.Purinoceptors,which participate in a variety of physiological and pathological processes,are widely distributed in human body,and have close association with migraine.In this paper,from the current domestic and foreign researches,the basic concept,classification and general physiological characteristics of purinoceptor are firstly introduced.And then,a series of pathophysiological processes in the attack of migraine are briefly described.And as a clue,detailed elaboration of different types of purinoceptors play a variety of roles respectively in these three main processes of diffuse cortical inhibition,activation of the trigeminal nerve vascular system and change of vascular function.At last,the research progress of the anti-migraine medicine based on purine energy signal is introduced.
