Mild hypothermia can decrease incidence of multiple organ dysfunction syndrome after intracerebral hemorrhage by up-regulating interleukin-10
10.3760/cma.j.issn.1671-8925.2016.05.013
- VernacularTitle:亚低温治疗通过上调IL-10表达水平降低脑出血后MODS发生率
- Author:
Liang WEI
1
;
Qi WANG
;
Cheng YANG
;
Yanfei ZHANG
;
Hongxin GUAN
;
Zhiyang SUN
Author Information
1. 同济大学附属上海市东方医院神经外科
- Keywords:
Intracerebral hemorrhage;
Mild hypothermia;
Multiple organ dysfunction syndrome;
Interleukin-10;
Adenovirus E4 promoter-binding protein 4
- From:
Chinese Journal of Neuromedicine
2016;15(5):494-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine whether mild hypothermia can decrease the incidence of multiple organ dysfunction syndrome (MODS) in patients after intracerebral hemorrhage.Methods Forty-eight patients with intracerebral hemorrhage,admitted to our hospital from March 2014 to December 2015,were divided into two groups:one was treated with mild hypothermia,and another was treated with normal methods after the surgery;the incidence of MODS was calculated between the two groups.Serum interleukin-10 (IL-10) levels were measured with enzyme-linked immunosorbent assay and E4 promoter-binding protein 4 (E4BP4) levels were measured with Simple Western in peripheral blood lymphocytes one,two,5,7,14 and 21 d after surgery.Results The incidence of MODS in patients with mild hypothermia treatment was 11.11％ and that in patients with normal treatment was 28.57％,with significant difference (P＜0.05).The IL-10 and E4BP4 levels in patients with mild hypothermia treatment were significantly higher than those in patients with normal treatment (P＜0.05).Conclusion Mild hypothermia can decrease the incidence of MODS in patients after intracerebral hemorrhage,IL-10 has some role,and E4BP4 is associated with release of interleukin-10.
