Surgical treatment of growth hormone pituitary tumors complicated with cardiomyopathy
10.3760/cma.j.issn.1671-8925.2016.05.009
- VernacularTitle:生长激素型垂体瘤合并心肌病外科手术治疗探讨
- Author:
Heping ZHOU
1
;
Xinsheng CHEN
;
Zhengsheng SHI
;
Zhengjiang ZHA
;
Jun WANG
Author Information
1. 安徽医科大学附属安庆医院神经外科
- Keywords:
Pituitary adenoma;
Growth hormone;
Cardiomyopathy
- From:
Chinese Journal of Neuromedicine
2016;15(5):478-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the surgical treatment of growth hormone (GH) pituitary tumors combined with cardiomyopathy patients and its clinical effect.Methods A total of 15 patients with GH pituitary tumors combined with cardiomyopathy were enrolled and underwent surgical treatment from February 2007 to May 2015 in our hospital.Pituitary endocrinology,brain magnetic resonance imaging,echocardiography diagram were inspected before and after surgery.Serum GH level,left ventricular diastolic diameter (LVIDd),thickness of the interventricular septum (IVST),left ventricular posterior wall thickness (LVPWT),left ventricular ejection fraction (EF),and mitral valve flow spectrum ratio (E/A) were detected by noninvasive methods and compared before and after treatment.Results Through the pituitary adenomas via nasal-sphenoid sinus surgery,total removal of the tumors were noted in 9 patients,subtotal resection in 4 patients,and partial resection in two patients.GH level,LVIDd,IVST,GH,LVPWT,E/A and EF after resection of pituitary tumor were significantly improved as compared with those before resection (P＜0.05).In the long-term follow-up,the cure rate was 35.68％,and the remission rate was 76.36％.Conclusion Surgical resection of pituitary tumor with good control of growth hormone levels can significantly improve the cardiac structure and function,thereby,GH pituitary tumor patients with cardiomyopathy can obtain satisfactory therapeutic effect.
