Wakening in severe craniocerebral injury coma patients by call stimulation
10.3760/cma.j.issn.1671-8925.2016.04.014
- VernacularTitle:呼唤刺激对重型颅脑损伤昏迷患者促醒的临床研究
- Author:
Zifeng DAI
1
;
Qilin HUANG
;
Haipeng LIU
;
Wei ZHANG
Author Information
1. 第三军医大学新桥医院神经外科
- Keywords:
Auditory stimuli;
Coma;
Severe traumatic brain injury
- From:
Chinese Journal of Neuromedicine
2016;15(4):397-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of call stimulate in arousal of coma patients after severe craniocerebral injury.Methods Twenty patients with severe craniocerebral trauma coma,admitted to our hospital from June 2014 to June 2015,were randomly divided into stimulation group (n=13) and control group (n=7).In addition to the regular relatives call stimulation,other treatments in stimulation group were the same as the control group.One,2,and 4 weeks after call stimulation,Glasgow Coma Scale (GCS) scores,blood flow velocity changes of internal carotid artery (ICA) and middle cerebral artery (MCA),and neurotransmitter contents of5-hydroxytryptamine (5-HT),dopamine (DA),norepinephrine (NE) and acetylcholine (Ach) in the cerebrospinal fluid (CSF) were detected.Results The consciousness was significantly improved in the stimulation group since the second week;at the 4th week,the GCS scores (11.85±2.58) were significantly higher than those in the control group (9.14±2.85,P<0.05).ICA and MCA blood flow velocity of both groups reached peak level in the first week,and then,gradually decreased till the end of the observation;ICA velocity value in the stimulation group (72.85± 7.45) was lower than that in the control group (82.14±11.61).The DA,Ach and NE content in the stimulation group were significantly increased at the 4th week as compared with those in the control group (P<0.05);but no significant difference was noted between the two groups in the content of 5-TH (P>0.05).Conclusion The call stimulus has certain awaking effect on coma patients,whose mechanism may be related to call induced changes of cerebral blood flow velocity and related neurotransmitter release.