Clinical and imaging features of 32 patients with central nervous system neurobrucellosis
10.3760/cma.j.issn.1671-8925.2016.03.013
- VernacularTitle:32例神经型布氏杆菌病(中枢型)的临床特点及影像学研究
- Author:
Yali LIAO
1
;
Shigang ZHAO
;
Zhelin ZHANG
Author Information
1. 内蒙古医科大学附属医院神经内科
- Keywords:
Neurobrucellosis;
Central nervous system;
Clinical characteristic;
Cerebrospinal fluid feature;
Neuroimaging
- From:
Chinese Journal of Neuromedicine
2016;15(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective The clinical characteristics of central nervous system neurobrucellosis (NB),such as incidence features,clinical symptoms,laboratory tests and imaging manifestations,are summarized to provide referenced clinical data for improving diagnosis standard.Methods Thirty-two in-patients with central nervous system NB were chosen in our hospital from March 2011 to December 2014.The clinical data were collected after they underwent some supplementary examinations,and then,follow-up was performed after 6 months of treatment.Results (1) The proportion of male and female was 5.5:1,and the average age was 50 years.(2) Twenty-four patients had onset with infectious of the central nervous system;another 8 had onset with cerebrovascular disease.(3) The clinical symptoms included fever,headache,nausea and vomiting and limb weakness;the signs included pathological syndrome,decreased muscle strength,and meningeal irritation sign.(4) All 32 NB patients underwent lumbar puncture,including 15 with normal cerebrospinal fluid pressure,and routine and biochemical examinations,4 with atypical NB cerebrospinal fluid changes,5 with NB early changes,and 6 with NB late changes.(5) Twenty-three patients appeared with positive imaging performance;15 patients were noted having lesions in the cortex,semi oval center,paraventricular and basal ganglia,3 in the spinal canal,one in the cervical spinal cord,two in the thoracic spinal cord,one in the cerebellar hemisphere and one in the dura mater.(6) After systematical treatment,one died,the other 31 recovered,of which 9 had different degrees of sequela.Conclusions NB is a part of the whole of Brucella infection.Its nonspecific clinical manifestations and extensive clinical syndrome bring some difficulties to definite diagnosis.Cerebrospinal fluid and neuroimaging examination are important evidences for the diagnosis.So it is necessary to study and understand these characteristics deeply to provide valuable data for early diagnosis and treatment of the disease.
