Recent advance in STAT3 signal pathway in glioblastomas
10.3760/cma.j.issn.1671-8925.2016.03.006
- VernacularTitle:STAT3信号通路在恶性脑胶质瘤中的研究进展
- Author:
Xiang WANG
1
;
Xiuming ZHOU
;
Xiejun ZHANG
;
Weiping LI
Author Information
1. 安徽医科大学附属深圳市第二人民医院临床医学院
- Keywords:
Glioblastoma;
Signal transducer and activator of transcription 3;
Signaling pathway
- From:
Chinese Journal of Neuromedicine
2016;15(3):245-250
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastomas remain the most clinically challenging primary brain tumors in adult,which has a dismal prognosis.Glioblastoma carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms.This review will explore the relationship between glioblastoma and both signal transducer and activator of transcription 3 (STAT3) signal pathway,and introduce the inhibition of glioblastoma growth through effectively inhibiting STAT3 signal transduct pathway.Besides,we further discuss the signal pathway related to STAT3.