Decreased sorting nexin 10 expression predicts poor clinical outcomes of patients with gliomas
10.3760/cma.j.issn.1671-8925.2016.03.004
- VernacularTitle:SNX10在神经胶质瘤中的表达及其对预后的影响
- Author:
Mingliang HE
1
;
Ming LUO
;
Leping OUYANG
;
Wangqing CAI
;
Yinlun WENG
;
Anmin LIU
Author Information
1. 中山大学附属孙逸仙纪念医院神经外科
- Keywords:
Sorting nexin 10;
Glioma;
Immunohistochemistry;
Prognosis
- From:
Chinese Journal of Neuromedicine
2016;15(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the sorting nexin 10 (SNX10) expression in glioma tissues and its relationship with prognosis of the patients.Methods Thirty glioma specimens,collected from surgery and conformed by pathology in our hospital from January 2007 to December 2012,were used in our study,and in them,9 were WHO grade Ⅰ and Ⅱ and 21 were WHO grade Ⅲ and Ⅳ;and 30 nonneoplastic tissue specimens collected during decompression were used as control group.Immunohistochemical staining using polyclonal SNX10 antibody was performed on paraffin embedded specimens.The staining intensity was stratified as absent (-),weak (+),moderate (++) and strong (4+++).The relationships of SNX10 expression with several clinic pathologic indicators and prognosis were analyzed.Results High SNX10 expression was noted in 12 specimens and low SNX10 expression in 18 specimens of the glioma group.High SNX10 expression was noted in 25 specimens and low SNX10 expression in 5 specimens of the control group;the high SNX10 expression rate in glioma tissues was significantly lower than that in non-neoplastic brain tissues (P＜0.05);the high SNX10 expression rate in high-grade glioma tissues was significantly lower than that in low-grade glioma tissues (P＜0.05).The median survival time ofglioma patients with high SNX10 expression was 22.50±8.27 months,and that of glioma patients with low SNX10 expression was 15.50±0.99 months.The survival rate of glioma patients with low SNX10 expression was significantly lower than that of glioma patients with high SNX10 expression (34％ vs.65％,P＜0.05).By Cox multi-factor risk scale model,the expression level of SNX10 and grading of tumors were identified as the independent risk factors of patient's post-operative death;following the decreased SNX10 expression,the risk of postoperative death increased 1.983 times (95％ confidence interval=1.602-2.314,P＜0.05).Conclusions Decreased SNX10 expression is associated with occurrence and development of gliomas,and has a significant effect on patients' post-operative survival time.Decreased SNX10 expression level may be an important index of poor prognosis in glioma patients.
