Risk factors of hemorrhagic transformation following defibrase therapy in patients with acute cerebral infarction
10.3760/cma.j.issn.1671-8925.2016.01.003
- VernacularTitle:急性脑梗死降纤治疗出血性转化的危险因素分析
- Author:
Haifei JIANG
1
;
Jin HUANG
;
Ping HUANG
;
Xiaohua QIU
;
Qifei QU
Author Information
1. 226000,江苏省南通市通州区人民医院神经内科
- Keywords:
Brain infarction;
Batroxobin;
Hemorrhagic transformation;
Risk factor
- From:
Chinese Journal of Neuromedicine
2016;15(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of hemorrhagic transformation (HT) following defibrase therapy in patients with acute cerebral infarction.Methods The clinical data of 245 patients with acute cerebral infarction,admitted to and treated with batroxobin in our hospital from March 2011 to May 2015,were summarized retrospectively.According to the intracranial hemorrhage under hospital CT scan or MRI,these patients were divided into HT group (n=18) and non-HT group (n=227).Influencing factors were analyzed by stepwise Logistic regression.The receiver operating characteristic (ROC) curve analysis on the independent risk factors was performed to obtain the optimum predictive value of HT following defibrase therapy.Results National Institutes of Health Stroke Scale (NIHSS) scores,sizes of cardioembolism,massive hemispheric infarction and cortical infarction,and fasting blood glucose level were statistically significant between HT and non-HT groups (P＜0.05).Logistic regression analysis demonstrated that NIHSS scores (OR=1.262,95％ CI=1.025-1.554,P=0.028) and size of cardioembolism (OR=3.949,95％CI=1.093-14.269,P=0.036) were independent predictors of HT following defibrase therapy in patients with acute cerebral infarction.The ROC curve showed that the optimal cutoffpoint of NIHSS scores to predict HT was 14.Conclusion Risk factors associated with HT following defibrase therapy in patients with acute cerebral infarction include high NIHSS scores and cardioembolism.
