Influence of exogenous taurine addition in amino acid content in brains of hypoxic-ischemic brain injury rats during lactation
10.3760/cma.j.issn.1671-8925.2015.12.011
- VernacularTitle:给予外源性牛磺酸对HIBD幼鼠脑内氨基酸含量影响的初步研究
- Author:
Hong LI
1
;
Wei ZHENG
;
Haiwen GUO
;
Jiang DU
;
Xiufen ZHANG
;
Siyun SHU
Author Information
1. 南方医科大学珠江医院儿科中心
- Keywords:
Taurine;
Hypoxic-ischemic brain injury;
Excitatory amino acid;
Inhibitory amino acid
- From:
Chinese Journal of Neuromedicine
2015;14(12):1240-1244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of exogenous taurine (TAU) on amino acid content in the brains of rats suffered hypoxic-ischemic brain injury (HIBD).Methods The 7-day-old SD rats were randomly divided into sham-operated group, control group and TAU treatment group.HIBD models in the later two groups were established following Rice-Vannucci method.On the basis of breastfeeding, TAU at 300 mg/(kg ·d) via tube feeding to the TAU treatment group and an equal volume saline solution to the sham-operated group and control group were given.The aspartic acid (ASP), glutamic acid (GLY), glycine (GLY), TAU and γ-aminobutyric acid (GABA) contents in the rat brains were measured by high-performance liquid chromatography at 48 h and 14 d after HIBD.Results At 48 h after HIBD, the TAU, ASP and GLU contents in the TAU treatment group were significantly increased as compared with those in the control group (P＜0.05);the GLU/TAU ratio in the TAU treatment group was significantly decreased as compared with that in the control group (P＜0.05).Fourteen d after HIBD, the TAU, GABA and GLY contents were significantly increased, the GLU content was significantly decreased, and the ASP/GLY, GLU/GLY and GLU/TAU ratios were significantly deceased in the TAU treatment group as compared with those in the control group (P＜0.05).Conclusion Exogenous TAU addition during lactation of rats suffered HIBD may improve contents of inhibitory amino acids as TAU, GABA and GLY, and modulate the ratio of main excitatory/inhibitory amino acids neurotransmitters.
