Regional homogeneity changes in patients with trigeminal neuralgia

VernacularTitle:三叉神经痛患者局部一致性研究
Author: Jianhao YAN ¹ ; Tianyue WANG ; Meng LI ; Guihua JIANG ; Wenfeng ZHAN
Author Information

1. 广东省第二人民医院影像科
Keywords: Trigeminal neuralgia; Functional MRI; Regional homogeneity; Regional spontaneous activity
From: Chinese Journal of Neuromedicine 2015;14(11):1144-1147
CountryChina
Language:Chinese
Abstract: Objective To explore the regional spontaneous activity changes in patients with trigeminal neuralgia (TN) using resting-state functional MRI.Methods Resting-state functional MRI datasets were acquired from 30 patients with TN,admitted to our hospital from July 2012 to December 2013,and 20 age,gender and education level matched healthy controls.The regional homogeneity (ReHo) method and independent-sample t-test were used to compare the brain activity differences between these two groups.Results Decreased ReHo values in the left temporal,left pam-hippocampal,as well as increased ReHo values in the bilateral thalamus and left parietal lobe were noted in TN patients as compared with those in the healthy controls.Conclusions The abnormal spontaneous activity exists in TN patients,and these abnormal regions are mainly associated with the perception and processing of pain.In addition,spontaneous activity alternation might promote the exploration of mechanism of TN.