Application of Xuebijing injection in severe craniocerebral injury patients with coagulation disturbance
10.3760/cma.j.issn.1671-8925.2015.09.015
- VernacularTitle:血必净注射液在重型颅脑损伤伴凝血功能异常患者中的应用
- Author:
Haobo JIANG
1
;
Mingyuan MA
;
Yunhai ZHANG
;
Menghua DENG
;
Na YU
;
Zhenhong QI
Author Information
1. 528000,佛山市中医院重症医学科
- Keywords:
Xuebijing injection;
Craniocerebral injury;
Coagulation disturbance;
Inflammation
- From:
Chinese Journal of Neuromedicine
2015;14(9):937-940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect of Xuebijing injection in severe craniocerebral injury patients with coagulation disturbance.Methods Sixty-five patients were randomly divided into Xuebijing treatment group (n=35) and control group (n=30).They all received regular treatment,while Xuebijing treatment group received Xuebijing injection additionally (0.9％ sodium chloride injection 100 mL adding 30 mL Xuebijing twice daily for a consecutive 10 d).Prothrombin time (PT),active partial thromboplastin time (APTT),levels of blood platelet (PLT),d-dimer (DD),tumor necrosis factor α (TNF-α),interldeukin (IL)-6 and IL-8,and Glasgow coma scale (GCS) scores at different time points,progressive intracranial hemorrhage (PIH) rate within 72 h,survival rate of 28 d were compared between two groups.Results Coagulation in all patients after treatment was significantly improved as compared with that before treatment (P＜0.05).At 72 h after treatment,the PT,APTT,and levels of DD and PLT in Xuebijing treatment group were significantly improved as compared with those in the control group (P＜0.05);levels ofTNF-α,IL-6 and IL-8 at 72 h after treatment in the treatment group ([1.41±0.32] ng/L,[80.4±25.1] ng/L and [5.17±0.59] ng/L) were significantly lower than those in the control group ([1.74±0.30] ng/L,[96.6±23.4] ng/L and [8.32±0.72] ng/L],P＜0.05).The PIH rate within 72 h in the treatment group (31.4％) was significantly lower than that in the control group (46.7％,P＜0.05).Conclusion Xuebijing injection could improve the abnormal coagulation and lower the PIH rate in severe craniocerebral injury patients with coagulation disturbance,possibly because Xuebijing injection could ameliorate inflammation.
