Prognostic significance of nestin in glioma patients: a Meta-analysis
10.3760/cma.j.issn.1671-8925.2015.09.003
- VernacularTitle:人脑胶质瘤中巢蛋白的表达与预后关系的Meta分析
- Author:
Guangtao ZHANG
1
;
Pengliang LI
;
Guangming YAO
;
Gang ZHAO
Author Information
1. 吉林大学第一医院神经外科
- Keywords:
Nestin;
Glioma;
Prognosis;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2015;14(9):874-878
- CountryChina
- Language:Chinese
-
Abstract:
Objective To objectively and systematically evaluate the prognostic significance of nestin in glioma patients with Meta-analysis.Methods A systematic literature search of PubMed/Medline,Web of Science,Cochrane Library and Google scholar was performed to recruit studies between January 1990 and May 2015 that evaluated the correlation of nestin with overall survival (OS) and progression-free survival (PFS) in glioma patients.A Meta-analysis (R-3.1.3) was conducted to analyze the prognostic significance of nestin in glioma patients.Results A total of 8 studies with the total number of 1313 patients met inclusion criteria.The analysis demonstrated negative associations between nestin high expression and both poor OS (hazard ratio [HR]=1.64,95％ confidence interval [CI] =1.27-2.12,P=0.0001) and PFS (HR=1.54,95％CI=1.04-2.28,P=0.0301).WHO grading was the main source of heterogeneity of OS data (P=0.0015),and the lower the WHO grade,the more significant the influence in OS.The sample capacity was the main source of heterogeneity of PSF data (P=0.008),and the larger the sample capacity,the more significant the influence in PFS.Conclusion The nestin expression can be used for accurately assessing the survival of glioma patients,thus,nestin could be recommended as a useful survival biomarker in clinical practice.
