Diagnostic value of biomarkers in cerebrospinal fluid in differentiating meningeal carcinomatosis and tubercular meningitis
10.3760/cma.j.issn.1671-8925.2015.08.012
- VernacularTitle:脑脊液生物学标志物对脑膜癌病与结核性脑膜炎的鉴别意义
- Author:
Junwei NIU
1
;
Qiang SHI
;
Chenglin TIAN
;
Ting CHEN
;
Lu CONG
Author Information
1. 解放军总医院神经内科
- Keywords:
Meningeal carcinomatosis;
Tubercular meningitis;
Cerebrospinal fluid;
Biomarker
- From:
Chinese Journal of Neuromedicine
2015;14(8):817-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value ofbiomarkers in cerebrospinal fluid in differentiating meningeal carcinomatosis (MC) and tubercular meningitis (TBM).Methods The clinical features and cerebrospinal fluid (CSF) test results of 34 patients with MC and 44 patients with TBM,admitted to our hospital from January 1994 to August 2014,were retrospectively analyzed and compared.Results The main clinical manifestations of MC included headache and bowel and bladder dysfunction,and those of TBM were fever and headache.The cell population of MC and TBM patients increased and the number of leucocyte of TBM patients was significantly larger than that of MC patients (P＜0.05);the CSF of all the patients presented with decreased levels of glucose and chloride,and increased protein level,and higher protein in MC patients was noted than that in TBM patients (P＜0.05).The biomarkers in CSF of MC and TBM patients increased to varying degrees,and the biomarkers,including carcinoembryonic antigen (CEA),cancer antigen (CA) 125,CA 199,CA 153 and CYFRA21-1,in MC group were significantly higher than those in TBM group (P＜0.05).The neuron-specific enolase level in the TBM patients of Ⅲ grade was significantly higher than that in the MC patients (P＜ 0.05).Conclusion The detections of tumor biomarkers in cerebrospinal fluid is a tool in differentiating MC and all stages of TBM,especially with the combined detections of CEA,CA125,CA199 and CYFRA21-1.
