Correlation analysis of ubiquitin carboxy-terminal hydrolase L1 level with severity, progression and prognosis of traumatic brain injury
10.3760/cma.j.issn.1671-8925.2015.07.012
- VernacularTitle:创伤性脑损伤UCH-L1水平与损伤程度、病情变化及预后的相关性分析
- Author:
Jinyu ZHENG
1
;
Liang QI
;
Hui HAN
;
Chunmei JI
;
Lin SHEN
;
Lixin LI
Author Information
1. 徐州医学院附属淮安医院神经外科
- Keywords:
Traumatic brain injury;
Biomarker;
Ubiquitin carboxy-terminal hydrolase L1;
Prognosis
- From:
Chinese Journal of Neuromedicine
2015;14(7):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of serum ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) level with severity,progression and prognosis of traumatic brain injury (TBI).Methods Sixty TBI patients,admitted to our hospital from March 2012 to June 2013,were chosen in our study,and divided into moderate TBI group (Glasgow coma scale [GCS] scores:9-12,n=30) and severe TBI group (GCS scores:3-8,n=30);30 healthy controls were chosen.The serum UCH-L1 levels 12 and 24 h,and 2,3 and 5 d after TBI were detected using enzyme-linked immunosorbent assay (ELISA).Additionally,the correlations between serum UCH-L1 level and both imaging data and prognosis of TBI were analyzed.Results As compared with that in the control group,the mean serum UCH-L1 level in moderate TBI group and severe TBI group 12 and 24 h,and 2 and 3 d after TBI was significantly increased (P＜0.05);as compared with that in the moderate TBI group,the serum UCH-L1 level in severe TBI group 12 and 24 h,and 2 and 3 d after TBI was significantly increased (P＜0.05).The serum UCH-L1 level in the moderate TBI group reached the peak at 12 h after TBI,then gradually declined and presented no significant difference 5 d after TBI in comparison with controls.In severe TBI group,serum UCH-L1 level reached the first peak at 12 h,then gradually decreased,and rose again for the second peak 3 d after TBI.Serum UCH-L1 level was closely related with imageological changes and negatively correlated with prognosis of TBI (r=-0.412,P=0.030).Conclusion Serum UCH-L1 level appears to have potential clinical utility in providing valuable information about severity,progression and prognosis of TBI.
