Association between mechanical stresses and brain burden of small vessel diseases
10.3760/cma.j.issn.1671-8925.2015.07.003
- VernacularTitle:颈总动脉血流机械动力学与脑小血管病负荷的相关性研究
- Author:
Houqin CHEN
1
;
Baiyun NI
;
Wenbing WANG
;
Fei GUO
Author Information
1. 241000,芜湖市第一人民医院神经内科
- Keywords:
Brain small vessel disease;
Wall tension;
Acute lacunar stroke;
Neuroimaging
- From:
Chinese Journal of Neuromedicine
2015;14(7):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between total burden of cerebral small vessel disease (cSVD) on brain MR imaging and circumferential wall tension (WT) in patients with acute lacunar stroke.Methods A total of 227 patients with first-ever acute lacunar stroke,admitted to our hospital from September 2010 to December 2012,were recruited in the study.All patients underwent conventional imaging sequences and susceptibility-weighted imaging sequences of 1.5T MRI system.The presences of each marker of cSVD,including asymptomatic lacunar infarct,white matter lesion,cerebral microbleed,and enlarged perivascular space,were scored on brain MRI.Internal diameters of the common carotid artery,and circumferential WT were measured.Logistic regression analysis was performed to determine the associations between WT levels and an increasing total burden of cSVD.Results According to cSVD scores,five groups of patients were concluded:6 with 0 point,37 with one point,103 with 2 points,61 with 3 points and 20 with 4 points;systolic WT in them were (5.79±0.24)×104 dyne/cm2,(5.70±0.49)×104 dyne/cm2,(5.89±0.71)×104 dyne/cm2,(7.12±i.19)×104 dyne/cm2 and (6.63± 0.76)×104 dyne/cm2,and diastolic WT in them were (3.37±0.31)×104 dyne/cm2,(3.29±0.26)×104 dyne/cm2,(3.50±0.43)×104 dyne/cm2,(3.99±0.49)×104 dyne/cm2 and (4.30±0.85)×104 dyne/cm2.Univariate analysis suggested that age,hypertension,diabetes,intemal diameters of the common carotid artery,diastolic WT and systolic WT had significant differences among the five groups (P＜0.05).After adjustment for confounding parameters,higher systolic WT (OR:1.555,95％CI:1.203～2.479) and higher diastolic WT (OR:5.287,95％CI:2.713～10.302) were associated with an increasing total burden of cSVD.Conclusions WT is associated with total burden of cSVD.
