Analysis of clinical factors influencing mid-long term pituitary hormone levels in patients after severe traumatic brain injury
10.3760/cma.j.issn.1671-8925.2015.06.015
- VernacularTitle:重型颅脑损伤中远期垂体激素变化的临床因素分析
- Author:
Guanqin LIANG
1
;
Jun PAN
;
Songtao QI
;
Yuntao LU
Author Information
1. 佛山市顺德区乐从医院神经外科
- Keywords:
Traumatic brain injury;
Mid-long term;
Pituitary hormone;
Clinical factors
- From:
Chinese Journal of Neuromedicine
2015;14(6):614-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of mid-long term pituitary hormone abnormalities in patients after severe traumatic brain injury (TBI) and its influencing clinical factors.Methods A total of 79 patients with severe TBI,admitted to our hospital from January 2011 to December 2013,were chosen in our research.Their basal levels of pituitary hormones,cortisol,testosterone,estradiol and free thyroxine 4 were detected in 6 months to 2 years after injury;and their clinical data were retrospectively analyzed by Chi-square test and multivariate Logistic regression analysis was employed to explore the incidence and types of pituitary hormone abnormalities,and the possible influencing factors.Results There were 35 patients with pituitary hormone abnormalities in 79 patients,with an incidence of 44.30％;the types of pituitary hormone abnormalities included prolactin in 18 patients (26.87％),thyroid stimulating hormone in 16 patients (23.88％),adrenocorticotropic hormone in 9 (13.43％),growth hormone in 8 (11.94％),and follicle stimulating hormone in 10 (14.93％) and luteinizing hormone in 6 (8.96％).Multivariate Logistic regression analysis showed that factors associated with pituitary hormone abnormalities following severe TBI in the mid-long term were diffused injury (OR=5.252,95％CI:1.176-23.465,P=0.030),brain hernia (OR=4.119,95％CI:1.261-13.452,P=0.019),subarachnoid hemorrhage (OR=3.966,95％CI:1.179-13.337,P=-0.026) and skull fracture (OR=4.222,95％CI:1.087-16.396,P=0.037).Conclusion Pituitary hormones following severe TBI are likely to be abnormal,and diffused injury,brain hernia,subarachnoid hemorrhage and skull fracture are the risk factors.
