Effect of dexmedetomidine on depth of sedation and hemodynamics in patients undergoing general anesthesia
10.3760/cma.j.issn.1671-8925.2015.05.018
- VernacularTitle:右旋美托咪啶对患者镇静效应和血流动力学的影响
- Author:
Huayong CHEN
1
;
Li LI
;
Jing ZHANG
Author Information
1. 潍坊医学院附属益都中心医院麻醉科
- Keywords:
Dexmedetomidine;
Sedation;
Propofol;
Hemodynamics
- From:
Chinese Journal of Neuromedicine
2015;14(5):516-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect ofdexmedetomidine (Dex) on depth of sedation and hemodynamics in patients undergoing general anesthesia with monitor of bispectral index.Methods Eighty patients with gliomas,admitted to our hospital from September 2011 to August 2013 and accepted surgery under general anaesthesia,were randomly divided into Dex group and control group (n=45).Patients from the Dex group received intravenous injection of 0.4 μg/kg before operation;and 5 min after that,Dex at a loading dose of 0.4 μg/kg was given for 30 min;and 0.9％ normal saline was given to the control group.The bispectral index (BIS),heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP),observer assessment of alertness/sedation (OAA/S) scores and Ramsay sedation scale scores were monitored before Dex infusion (T0) and after loading (T1),and at 10,20,30 min (T2-T4) after continuous infusion.Results As compared with those in the control group,the BIS and OAA/S scores in the Dex group was significantly decreased,and the Ramsay sedation scale scores were statistically increased at T1,T2,T3 and T4 (P＜0.05);the HR at T1,T2,T3 and T4 was slower and the SBP at T1 and T2 was higher in the Dex group than those in the control group,with significant differences (P＜0.05).SBP at T3 and T4 and DBP at T1,T2,T3 and T4 showed no significant difference between the two groups (P＞0.05).Conclusion Intravenous Dex can make conscious patients has obvious sedative effects,deepen anesthesia depth of anesthesia surgery patients and reduce the dosage of propofol,and can cause HR decreasing.
