CT perfusion imaging at the interphase of patients with transient ischemic attacks
10.3760/cma.j.issn.1671-8925.2015.05.012
- VernacularTitle:短暂性脑缺血发作患者发作间期CT灌注成像研究
- Author:
Yuxia LI
1
;
Yongqiu LI
;
Jie LU
;
Ying HAN
Author Information
1. 063000,唐山市工人医院神内一科
- Keywords:
CT perfusion;
Transient ischemic attacks;
Interphase
- From:
Chinese Journal of Neuromedicine
2015;14(5):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of CT perfusion (CTP) at the interphase in patients with transient ischemic attack (TIA) by applying 16 multi-slice spiral CT.Methods Sixty-nine TIA patients,admitted to our hospital from October 1,2011 to December 30,2012,were performed CTP;cerebral blood flow (CBF),cerebral blood volume (CBV),mean transit time (MTT) and time to peak (TTP) were measured within specific regions of the brains.Staging was performed according to the CTP results;the relationship between abnormal CTP and clinical symptoms of TIA patients was analyzed.Results In 69 patients with TIA,persisting abnormal perfusion changes corresponding to clinical symptoms were found in 52 patients.According to the CTP results,stage Ⅰ TIA included 25 patients and stage Ⅱ included 27 patients;the TTP and MTT in stage Ⅰ patients were significantly different between the affected side and the contralateral side (P＜0.05),while the CBF and CBV showed no significant difference (P＞0.05);the TTP,MTT and CBF in stage Ⅱ patients were significantly different between the affected side and the contralateral side (P＜0.05),while CBV showed no significant difference (P＞0.05).The percentages of stage Ⅱ patients with National Institutes of Health Stroke Scale (NIHSS) scores higher or equal to 4 points (68.2％) and onset duration longer than 60 min during TIA (75.0％) were significantly higher than those of stage Ⅰ patients (31.8％,25％,P＜0.05).NIHSS scores and duration of TIA onset were negatively correlated with the CBF ratio (affected/contralateral side;r=-0.548,P=0.000;r=-0.848,P=0.000),positively correlated with the TTP ratio (affected/contralateral side;r=0.732,P=0.000;r=0.927,P=0.000),and positively correlated with the MTT ratio (affected/contralateral side;r=0.668,P=0.000;r=0.902,P=0.000) in 52 TIA patients.Conclusion CTP provides valuable hemodynamic information,which could be used as the imaging basis of TIA diagnosis and treatment.
