Time window of hyperbaric oxygen in treatment of persistent vegetable state and its treatment efficacy: a Meta analysis
10.3760/cma.j.issn.1671-8925.2015.04.014
- VernacularTitle:高压氧治疗植物状态临床疗效及时间窗的Meta分析
- Author:
Yi YANG
1
;
Jianghong HE
;
Hui JIAO
;
Xiaoyu XIA
;
Yuanyuan DANG
;
Yiwu DAI
;
Ruxiang XU
Author Information
1. 北京军区总医院附属八一脑科医院
- Keywords:
Persistent vegetative state;
Hyperbaric oxygen;
Time window;
Meta analysis
- From:
Chinese Journal of Neuromedicine
2015;14(4):501-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review systematically the clinical curative effects and time window of hyperbaric oxygen treatment of persistent vegetative state (PVS).Methods All the clinical research articles about hyperbaric oxygen for PVS from January 1990 to December 2013 were retrieved from China national knowledge internet,Wanfang Database and Vip Database (the Chinese key words:vegetative state,the vegetable,or hyperbaric oxygen),and then,a Meta-analysis was conducted.Results Search terms yielded 165 pieces of articles and 19 were included in the final analysis for treatment efficacy;the treatment group included 939 patients and the control group included 659 patients.Totally,17 pieces of articles of time window were included;the patients with onset＜60 d group included 700 patients and the patients with onset＞ 60 d group included 330 patients.The Jadad scores of included articles were not high in general,and the highest scores were two points.Comparable baseline data were demonstrated in all of the articles.Data from articles were pooled and analyzed,and the results showed that the effective rate of treatment group and control group were 67.51％ and 34.45％,with significant difference (Z=12.16,P=0.000,odd ratio=0.25,95％ confidence interval=0.20-0.31).The effective rate of patients with onset＜60 d group and patients with onset≥60 d group was 22.73％ and 63.29％ (Z=9.72,P=0.000,odd ratio=5.21,95％ confidence interval=3.74-7.27) Conclusion Hyperbaric oxygen treatment enjoys better treatment efficacy than conventional treatment;patients with onset＜60 d have better prognosis than patients with onset≥ 60 d.
