Expressions of nucleostemin and p53 up-regulated apoptotic factor proteins in human gliomas and clinical significance
10.3760/cma.j.issn.1671-8925.2014.12.016
- VernacularTitle:NS和PUMA蛋白在人脑胶质瘤中的表达及其临床意义
- Author:
Sen CHENG
1
;
Jixin SHOU
;
Xudong FU
;
Jian MA
;
Shaolong ZHOU
Author Information
1. 郑州大学第五附属医院神经外科
- Keywords:
Nucleostemin;
P53 up-regulated modulator of apoptosis;
Glioma;
Immunohistochemistry
- From:
Chinese Journal of Neuromedicine
2014;13(12):1256-1259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions ofnucleostemin (NS) and p53 up-regulated apoptotic factor (PUMA) proteins in human gliomas and its clinical significance.Methods Sixty-two human gliomas,collected in our hospital from January 2011 to February 2013 and confirmed by pathology,were used in our study; according to the WHO grading,grade Ⅰ included 8 patients in the study group,grade Ⅱ 21 patients,grade Ⅲ 19 patients and grade Ⅳ 14 patients.Other 10 patients accepted decompressions in our hospital at the same time period were used as control group.The expressions of NS and PUMA proteins in the brain tissues were detected by immunohistochemical S-P method.Results The NS protein expression was significantly higher and PUMA protein expression was statistically lower in study group than those in the control group (P＜0.05).As compared with gliomas of grade Ⅰ and Ⅱ,gliomas of grade Ⅲ and Ⅳ had significantly higher NS protein expression and lower PUMA protein expression (P＜0.05).Conclusions The expression changes of NS and PUMA are closely associated with gliomas malignant degrees,and the two play important roles in the progression and proliferation of glioma cells.
