Relationship between SG13S32 locus polymorphisms of 5-lipoxygenase-activating gene and ischemic stroke in Xinjiang Uygur
10.3760/cma.j.issn.1671-8925.2014.12.012
- VernacularTitle:5-脂氧合酶激活蛋白基因SG13S32位点多态性与维吾尔族缺血性脑卒中发病的相关性研究
- Author:
Meng LIU
1
;
Jianhua MA
;
Xiaoning ZHANG
;
Qimeng SUN
Author Information
1. 新疆医科大学第一附属医院神经内科
- Keywords:
5-1ipoxygenase-activating gene;
Single-nucleotide polymorphism;
Ischemic stroke;
Uygur
- From:
Chinese Journal of Neuromedicine
2014;13(12):1239-1242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the 5-lipoxygenase-activating (ALOX5AP) gene polymorphisms with ischemic stroke in Uygur Xinjiang.Methods One hundred and ninety-seven Uygur patients with ischemic stroke and 200 Uygur healthy controls in Xinjiang were collected in our study from October 2011 to October 2012.The SG13S32 locus polymorphisms of A LOX5A P gene were determined by using PCR-restriction fragment length polymorphism technique.The case-control analysis was used to analyze the genotypes distributions and allele frequencies.Results There were statistical differences in the distributions of AC genotypes of SG13S32 locus in ALOX5AP gene between patient group and control group (P＜0.05) and AC genotypes of SG13S32 locus in ALOX5AP gene significantly increased the risk of ischemic stroke (OR=5.27,95％CI:2.75-11.73).The distributions of all genotypes showed no statistical differences between male and female in the patient group (P＞0.05).The distributions of all genotypes showed no statistical differences between patients of different TOAST ratio (P＞0.05).Conclusion The ALOX5A P gene SG13S32 locus polymorphisms are associated with risk of ischemic stroke in Xinjiang Uygur population; risk of ischemic stroke does not associate with gender and TOAST ratio.
