Influence of gender in cortical spreading depression wave in mice
10.3760/cma.j.issn.1671-8925.2014.11.009
- VernacularTitle:性别因素对小鼠大脑皮层扩散性抑制波的影响
- Author:
Jianping LYU
1
;
Zhikai CAO
;
Zhixiong JIA
;
Peng LI
;
Haixia ZHANG
Author Information
1. 510180,广州市第一人民医院神经外科
- Keywords:
Spreading depression;
Gender;
Mouse
- From:
Chinese Journal of Neuromedicine
2014;13(11):1123-1126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of gender in cortical spreading depression (SD) wave in mice.Methods Potassium chloride (KCl) or middle cerebral artery occlusion (MCAO) models were used to induce SD.Adult C57 mice were randomly divided into four groups:male and female KCl-induced groups,male and female MCAO-induced groups (n=8).SD waves were monitored for 2 h by electrophysiological method.Results SD waves showed lower amplitude and longer duration time in the MCAO-induced group as compared with those in the KCl-induced group.There were no obvious differences in SD amplitude,duration time,frequency and onset time of first SD between male and female KCl-induced groups (P＞0.05).There were no differences in SD amplitude and duration time between male and female MCAO-induced groups (P＞0.05),however,SD frequency and onset time of the first SD were signficantly different between male and female MCAO-induced group (P＜0.05).Conclusion Mice gender has an effect on MCAO-induced SD,but no obvious effect on KCl-induced SD; the possible explanation for the difference is that estrogens modifying susceptibility to SD is mainly through their effect on glutamate but not on K+ metabolic pathways.
