Expressions of stromal-cell derived factor-1α and its receptor CXCR4, hypoxia inducible factor-1α and vascular endothelial growth factor in brain arteriovenous malformation
10.3760/cma.j.issn.1671-8925.2014.11.006
- VernacularTitle:SDF-1α及其受体CXCR4与HIF-1α、VEGF在脑动静脉畸形中的表达
- Author:
Lingyan WANG
1
;
Shaolei GUO
;
Tiewei QI
;
Feng LIANG
;
Zhengsong HUANG
Author Information
1. 中山大学附属第一医院神经外科ICU
- Keywords:
Brain arteriovenous malformation;
Stromal-cell derived factor-1α;
CXCR4;
Hypoxia inducible factor-1α;
Vascular endothelial growth factor
- From:
Chinese Journal of Neuromedicine
2014;13(11):1107-1111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions ofstromal-cell derived factor-1α (SDF-1α)and its receptor CXCR4 in brain arteriovenous malformation (AVM) and to explore the relationships of SDF-1α with hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF).Methods Surgical specimens from 48 patients accepted brain AVM resection,collected in our hospital from January 2012 to December 2013,were studied for expressions ofSDF-1α,CXCR4,VEGF and HIF-1α by immunohistochemical staining.The relationships of SDF-1α with VEGF and HIF-1α were analyzed and influences of embolism,hemorrhage and Spetzer-Martin classification in SDF-1α expression were assessed.Results SDF-1α and CXCR4 expressed in 100％ and 83.3％ AVM specimens,respectively.The positive staining for SDF-1α was observed in the cytoplasm of vascular endothelium within the nidus and smooth muscle cells of vascular wall.CXCR4 expressed in vascular endothelium and perivascular cells located in the space between the abnormal vessels.SDF-1α expression was significantly associated with VEGF and HIF-1α (r=0.537 and 0.437,respectively,P＜0.05).SDF-1α showed more intense expression in embolized patients than that in non-embolized patients (P＜ 0.05),while no significant difference was noted between patients with and without hemorrhage and between patients of different Spetzer-Martin classifications (P＞0.05).Conclusion SDF-1α and its receptor CXCR4 highly express in brain AVM; preoperative embolization might induce expression of SDF-1α.
