Repetitive transcranial magnetic stimulation in treatment of schizophrenia with refractory negative symptoms: a brain-derived neurotrophic factor level study
10.3760/cma.j.issn.1671-8925.2014.10.013
- VernacularTitle:重复经颅磁刺激对精神分裂症患者血清脑源性神经营养因子的影响
- Author:
Huifeng DUAN
1
,
2
;
Jingli GAN
;
Yajun LIAN
;
Zhenjuan SHI
;
Cunyou GAO
;
Yi ZHANG
;
Yanlun GAO
Author Information
1. 450052郑州,郑州大学第一附属医院神经内科
2. 454003焦作,解放军第九十一中心医院精神科,全军精神疾病防治研究所
- Keywords:
Transcranial magnetic stimulation;
Schizophrenia;
Brain derived neurotrophic factor;
Refractory negative symptom
- From:
Chinese Journal of Neuromedicine
2014;13(10):1030-1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) on serum brain-derived neurotrophic factor (BDNF) level in patients with schizophrenia.Methods Eighty hospitalized schizophrenics with refractory negative symptoms,admitted to our hospital from September 2012 to October 2013 and met the diagnostic and statistical manual of Mental Disorders-4th Edition (DSM-Ⅳ),were randomly divided into study group (n=40) and sham-operated group (n=40).The rTMS of 10 Hz on left prefrontal lobe was performed in study group and sham stimulation was used in sham-operated group; and the kinds and dosages of antipsychotics were preserved as before; other 40 healthy subjects were used as control group.Positive and Negative Syndrome Scale (PANSS) was performed and serum BDNF level was measured before and 4 weeks after treatment in all patients.Results BDNF level in both study group and sham-operated group before and after treatment was significantly lower than that in the control group (P＜0.05).The total PANSS scores and negative symptom scale scores in the study group after treatment were significantly decreased as compared with those before treatment (71.2±13.8 vs.63.3±11.4,t=2.721,P=0.008; 18.4±5.9 vs.22.8±6.6,t=3.064,P=0.003),and the BDNF level was statistically increased (8.74±2.76 vs.6.78±2.16,t=3.447,P=0.001).After treatment,the study group had significantly lower negative symptom scale scores and higher BDNF concentration than sham-operated group (t=2.470,P=0.016; t=3.180,P=0.002).For total PANSS scores,negative symptom scale scores and general psychopathology scale scores,the changed values before and after treatment of study group were all significantly higher than those in the sham-operated group (7.8±3.5 vs.2.0±0.9,t=9.893,P=0.000; 4.4±1.9 vs.0.5±0.2,t=12.584,P=0.000; 2.8±1.0 vs.0.9±0.4,t=10.875,P=0.000).For the study group,the changes of BDNF concentration showed no obvious correlation with the total PANSS scores or negative symptom scale scores (r=-0.156-0.247,P＞0.05).Conclusions The rTMS of 10 Hz on the left prefrontal lobe can increase the serum BDNF concentration of the schizophrenia.There is no correlation between the changes of BDNF concentration and improved negative symptoms.
