A meta-analysis on whether migraine is associated with white matter abnormality in MR imaging
10.3760/cma.j.issn.1671-8925.2014.09.015
- VernacularTitle:偏头痛与MRI脑白质异常信号关系的Meta分析
- Author:
Sheng LI
1
;
Wei LIU
;
Jianxin XIAO
;
Xiuyun CHEN
Author Information
1. 解放军第一一八医院神经内科
- Keywords:
Migraine;
White matter abnormality;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2014;13(9):934-938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between migraine and abnormal white matter signal in MR imaging.Methods The controlled trail was performed on the relevant cases selected from the data bases of PubMed,Ovid,VIP,CNKI,and then,meta-analysis was implemented.Results The general evaluation showed that patients with migraine had a high trend of abnormal white matter signal in MR imaging as compared with the normal controls (occurrence rate [OR]=3.3,Z=4.53,P=0.000 and fail-safe number [Nfs]=191).After excluding other complications those might cause abnormal white matter signal,the OR reached to 4.24 (Z=4.110,P=0.000 amd Nfs=124).As the same as the evaluation of significant difference in Chinese journals (OR=4.92,Z=3.370,P=0.001 and Nfs=5),the English journals also revealed this difference was statistically significant (OR=3.07,Z=3.930,P=0.000 and Nfs=124).The difference was significant if abnormal white matter signal was associated with migraine with aura (OR=3.870,Z=3.38,P=0.001 and Nfs=102) and without attra (OR=2.50,Z=3.482,P=0.001 and Nfs=64).Conclusion Migraine is a risk factor for white matter abnormalities; patients with migraine with aura are at greater risk than those with migraine without aura.
