Clinical significance of vasculogenic mimicry expression in human gliomas
10.3760/cma.j.issn.1671-8925.2014.09.014
- VernacularTitle:脑胶质瘤组织中血管生成拟态的表达及临床意义
- Author:
Ting LI
1
;
Yinli LIANG
;
Li YU
Author Information
1. 湖南省常德市第一人民医院肿瘤科
- Keywords:
Gliomas;
Vasculogenic mimicry;
Ki-67;
Prognosis
- From:
Chinese Journal of Neuromedicine
2014;13(9):929-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significances ofvasculogenic mimicry (VM) and Ki-67 expression in human gliomas.Methods Sixty-three specimens of human gliomas with adequate clinical and pathological data,collected in our hospital from January 2008 to December 2012,were chosen.VM in the glioma samples was determined by dual staining of periodic acid-Schiff (PAS) and endothelial marker CD34,and Ki-67 protein expressions by SP immunohistochemical staining.The association between VM and clinical characteristics of the patients were analyzed.Results VM channels were found in 13 specimens of human gliomas (20.63％),and it was correlated with tumor grade and tumor recurrence (P＜0.05):high incidence of VM in high-grade gliomas (WHO Ⅲ,19％; WHO Ⅳ,33.3％) was noted as compared with that of lower-grade gliomas (WHO Ⅱ,6.7％); patients with VM were more prone to tumor recurrence (28.6％) as compared with those without VM (4％).A positive relationship between Ki-67 expression and VM was revealed (r=0.531,P=0.000).Kaplan-Meier survival analysis showed that both progression-free survival and overall survival of VM-positive group were significantly shorter than those of VM-negative group (P＜0.05).Cox proportional hazards model analysis indicated that VM was an independent prognostic factor of human gliomas (P=0.020).Conclusion The presence of VM in human gliomas tissues is proved; combined detection of VM and Ki-67 expression can contribute to evaluate the risk of tumor recurrence,and simultaneously be some new indicator of predicting the prognosis of human gliomas.
