Recovery of oculomotor nerve palsy after endovascular treatment of posterior communicating artery aneurysms and curative effect of mecobalamine treatment
10.3760/cma.j.issn.1671-8925.2014.07.019
- VernacularTitle:甲钴胺治疗后交通动脉瘤性动眼神经麻痹患者术后恢复情况的临床观察
- Author:
Shouan WANG
1
;
Chengyan LI
;
Guibing ZHANG
;
Peiyang ZHOU
;
Pu WANG
;
Jun YANG
;
Yuhua FENG
Author Information
1. 武汉大学人民医院神经内科
- Keywords:
Intracranial aneurysm;
Oculomotor nerve palsy;
Embolization;
Prognosis;
Mecobalamine
- From:
Chinese Journal of Neuromedicine
2014;13(7):713-716
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the evolution of oculomotor nerve paresis (ONP) after endovascular packing of posterior communicating artery aneurysms (PcomA) to prospectively evaluate the effect of mecobalamine treatment on ONP prospective recovery.Methods A total of 56 patients with ONP attributable to PcomA,treated with coils in our hospital from July 2007 to January 2013,were enrolled in a randomized,controlled open study,and 55 of them got follow up;embolization+mecobalamine treatment was performed in 28 and embolization treatment was in 27.The degrees of ONP were recorded one year after treatment.Results All patients succeeded in one year follow-up; 31 patients (56.4％) achieved complete resolution of ONP,19 (34.5％) partial improvement and 5 (9.1％) no changes.The complete recovery rate in the embolization+mecobalamine treatment group was 71.4％ (20/28) and that in the embolization treatment group was 40.7％ (11/27),with statistically significant differences (P＜0.05).Conclusion Endovascular treatment is highly efficacious in treating ONP-inducing PcomA and mecobalamine treatment can promote the recovery of oculomotor nerve palsy after embolism.
