Effect of propofol on minimum threshold of inferior colliculus neuron discharge in rats
10.3760/cma.j.issn.1671-8925.2014.06.007
- VernacularTitle:丙泊酚对大鼠下丘神经元放电阈值的影响
- Author:
Xinjian ZHANG
1
;
Yuanxin ZHANG
;
Li SHENG
;
Miaoning GU
Author Information
1. 济南军区总医院
- Keywords:
Propofol;
Inferior colliculus;
Neuron;
Threshold
- From:
Chinese Journal of Neuromedicine
2014;13(6):568-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect ofpropofol on minimum threshold (MT) of the inferior colliculus neuron discharge in rats.Methods Forty-three healthy SPF grade Sprague Dawley (SD) rats,weighing 200-250 g,were chosen in our study and established wakeful animal models by ventilating with animal respirator after infusing vecuronium.A microelectrode was penetrated in the inferior colliculus (ICC),and then,MT of the inferior colliculus neuron discharge was noted using a Tucker-Davis Technologies System 3 before intraperitoneal injection of propofol 100 mg/kg and after administration.Results Characterizing fiequency of the neurons (12.06±8.77 kHz) was positively correlated to depth of the recording electrode (3435.65±651.00 μm; r=0.581,P=0.000); discharge threshold can be determined in 30 of 43 neurons,and the threshold values under awake and anesthetized states were 36.8±20.4 dB SPL and 40.4±20.5 dB SPL,respectively,with significant differences (P＜0.08).The intercept of the linear regression line is significantly more than 0 corresponding to the diagonal one (P＜0.05).Conclusion Propofol affect auditory information transmission by increasing neuronal response MT and reducing excitability in ICC,which is possibly an important factor leading to heating disappear.
