Three-dimensional reconstruction of subthalamic nucleus for optimal electrode angle of deep brain stimulation in Parkinson's disease patients
10.3760/cma.j.issn.1671-8925.2014.06.002
- VernacularTitle:基于丘脑底核三维重建图的帕金森病患者深部脑刺激穿刺电极角度的规划研究
- Author:
Dongyang LIU
1
;
Fengfei LU
;
Shizhong ZHANG
Author Information
1. 510280广州,南方医科大学珠江医院神经外科,广东神经外科研究所,广东省脑功能修复与再生重点实验室
- Keywords:
Parkinson's disease;
Deep brain stimulation;
Subthalamic nucleus;
Three-dimensional reconstruction
- From:
Chinese Journal of Neuromedicine
2014;13(6):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the parameters of the specific electrode trajectory angles under the condition that the trajectory length in the nuclei could be as long as possible by using 3D reconstruction of subthalamic nucleus (STN).Methods A 3D atlas of deep brain nuclei was built on the 3D reconstruction station,and the parameters of STN were measured.MR imaging of 30 Parkinson's disease (PD) patients was matched to the 3D atlas to acquire the average nucleus information.Results The STN spatial location parameters showed no significant statistical difference with imaging of these 30 patients (95％ confidence interval of difference value＜l),indicating that this 3D atlas enjoyed good representative value.After simulation,the optimal trajectory angles were achieved:the combination angles ofring/slide:55°-57°/17°-19°,which extended the trajectory within the nucleus to about (5.7±0.3)mm.Conclusion The 3D atlas shows high representative of locating deep brain nucleus and could be registrated well to particular patient's images.After simulation on the atlas,the optimal trajectory angles parameters can be obtained,which shows the specific operation of achieving longer length of electrode in nucleus.
