Effects of combination therapy of deanxit and analgecine on elderly painful diabetic peripheral neuropathy
10.3760/cma.j.issn.1671-8925.2014.05.020
- VernacularTitle:黛力新联合恩再适治疗老年痛性糖尿病周围神经病变的临床研究
- Author:
Xiaozhu SHEN
1
;
Changrong TIAN
;
Xin WANG
Author Information
1. 222006,连云港市第二人民医院老年医学科
- Keywords:
Diabetes mellitus;
Peripheral neuropathy;
Deanxit;
Analgecine;
Elderly;
Synergistic effect
- From:
Chinese Journal of Neuromedicine
2014;13(5):522-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of combination therapy of deanxit and analgecine on elderly painful diabetic peripheral neuropathy (PDPN).Methods One hundred and eighty PDPN patients,admitted to our hospital from January 2010 to May 2012,were chosen in this study; they were randomly divided into Group A (control group,n=60),Group B (analgecine treatment group,n=60) and Group C (deanxit and analgecine combined treatment group,n=60).On the basis of controlling the plasma glucose of all subjects,Group A was treated with methycobal 0.5 mg intramuscular injection once a day,three times a week for 12 weeks; Group B was treated with analgecine 3 mL intramuscular injection once a day for 2 weeks and then rested for 2 weeks,which repeated for three courses; Group C was treated with deanxit orally 1 capsule every morning and analgecine in the same way with Group B.The evaluation and analysis of the efficacy (mental state,quantitative sensory,scores of visual analog scale of pain intensity [VASPI],and nerve conduction velocity) and safety (nausea,dry mouth,diarrhea,dizziness,headache,drowsiness,fatigue,tremors,blurred vision,neutropenia,and liver dysfunction) of all patients were carried out after 12 weeks.Results (1) The anxiety and depression scale scores of Group C 12 weeks after treatment were significantly lower than those of Group A and Group B (P＜0.05).(2) After 12 weeks of treatment,cold sensation in Group B and Group C was significantly higher than that in Group A,while thermal sensation and cold pain sensation in Group B and Group C were significantly lower than those in Group A (P＜0.05).(3) VASPI scores in group C were significantly lower than those in Group A and Group B at the 1st,2nd,4th,8th and 12th weeks (P＜0.05).(4) No significant difference was observed in nerve electrophysiological examination before and 12 weeks after treatment in all 3 groups (P＞0.05).(5) One patient in Group C appeared neutropenia two weeks after treatment,but the granulocyte rose to normal after stopping the deanxit for one week; no other abnormal condition was found in the observation period.Conclusion Combination therapy of deanxit and analgecine on elderly PDPN achieves good clinical effect and it is safe using in the elderly.
