Oxcarbazepine oral suspension in partial epilepsy of preschool-aged children: an efficacy and safety study
10.3760/cma.j.issn.1671-8925.2014.04.017
- VernacularTitle:奥卡西平混悬液治疗学龄前儿童癫痫疗效及安全性研究
- Author:
Jian CHEN
1
;
Liping ZOU
;
Meng ZHAO
;
Jun JU
Author Information
1. 解放军总医院儿童医学中心
- Keywords:
Epilepsy;
Oxcarbazepine;
Oral suspension;
Preschool-aged children;
Self-control study
- From:
Chinese Journal of Neuromedicine
2014;13(4):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy,tolerability and safety of oxcarbazepine oral suspension in partial epilepsy of preschool-aged children.Methods Forty-eight preschool-aged children with partial epilepsy,admitted to out hospital from August 2009 to August 2012,were chosen in our study; they were treated with oxcarbazepine oral suspension with an initial dose of 10 mg/(kg?d),and a maintenance dose of 30-40 mg/(kg,d).The efficacy,adverse reactions,tolerability and safety 3 and 6 months after treatment were investigated,and compared with the controls (the frequency of epileptic seizures of these children 3 months before treatment).The treatment outcomes were evaluated by seizure frequency as completely seizure free (100％ seizure reduction),markedly effective (75％-99％ seizure reduction),effective (50％-74％ seizure reduction) and invalid (＜50％ seizure reduction).Results The completely seizure free rates for 3 and 6 months after treatment were 41.7％ and 50％,and the total effective rates (completely seizure free+ markedly effective+ effective) were 79.2％ and 79.2％.Three patients gave up treatment because of rash.Adverse reactions occurred in 12 patients (25％),including rash,increased sleep,anorexia and blurred vision,which were transient and mild.Conclusion Treatment of oxcarbazepine oral suspension is safe and reliable on epilepsy with mild adverse reactions and good compliance in preschool-age children.
