Fraction amplitude of low-frequency fluctuation in irritable bowel syndrome patients: a restingstate fMRI study
10.3760/cma.j.issn.1671-8925.2014.03.016
- VernacularTitle:肠易激综合征患者静息态功能磁共振成像比率低频振幅研究
- Author:
Xiaofen MA
1
;
Guihua JIANG
;
Shumei LI
;
Jin FANG
;
Wenfeng ZHAN
;
Junzhang TIAN
;
Yingwei QIU
Author Information
1. 广东省第二人民医院影像科
- Keywords:
Irritable bowel syndrome;
Functional magnetic resonance imaging;
Fractional amplitude of low frequency fluctuation;
Resting state
- From:
Chinese Journal of Neuromedicine
2014;13(3):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the pathological mechanism of brain function in irritable bowel syndrome (IBS) patients by analyzing the fraction amplitude of low-frequency fluctuation (fALFF) of functional magnetic resonance imaging (fMRI) raw data in resting state.Methods The fMRI at resting state was performed in 21 IBS patients and 21 age-,education-and sex-matched normal healthy subjects,collected in our hospital from August 2010 to April 2012.The scan sequence in this study was single-shot echo planar image.The DPARSF software was used to preprocess the fMRI data,and then,the fALFF was compared between the IBS and normal control groups.Results As compared with the control group,the IBS group showed significantly increased fALFF values in the primary somatosensory cortex region and secondary somatosensory cortex region such as right temporal pole,middle temporal gyrus,precentral gyrus,postcentral gyrus and right superior frontal gyrus,and decreased fALFF values in the cerebellum.Conclusion Some somatosensory cortex regions in the IBS group are abnormal in the resting state in IBS patients,which can reflex a few pathological changes of brain dysfunction,and it also helps to understand IBS from the perspective of the brain neural activity for clinic diagnosis.
