Efficacy and safety of vinpocetine in treatment of patients with acute cerebral infarction
10.3760/cma.j.issn.1671-8925.2014.03.012
- VernacularTitle:长春西汀(开文通)治疗急性脑梗死的疗效与安全性的临床研究
- Author:
Nan LIU
1
;
Weiwei ZHANG
;
Wei WEI
;
Yazhou WEI
;
Weimin YIN
Author Information
1. 北京军区总医院神经内科
- Keywords:
Vinpocetine(Cavinton);
Acute cerebral infarction;
Clinic research
- From:
Chinese Journal of Neuromedicine
2014;13(3):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of vinpocetine (Cavinton) in treatment of patients with acute cerebral infarction.Methods Six hundred and ten patients with acute cerebral infarction (within 48 h to 14 d of onset),admitted to 17 hospitals from July 31,2010 to November 27,2012,were recruited and randomly allocated into 2 groups:control group (n=141) and therapy group (n=469).Patients in the control group were treated with citicoline for 14 d,and those in the therapy group were treated with citicoline combined with 30 mg cavinton via intravenous drip once daily for 14 d.The outcomes were evaluated according to Mini-mental State Examination (MMSE),National Institute of Heath Stroke Scale (NIHSS),modified Rankin scale (mRS) and Barthel index before treatment and 7,14 and 90 d after symptom onset,respectively.Results Significant difference in mRS scores was noted between therapy group (1.85±1.28) and control group (1.97±1.23) 14 d after treatment (P＜0.05).There were significant differences in scores of MMSE,NIHSS and Barthel index between therapy group (27.42±5.24,1.37±2.08 and 7.21 ±17.29) and control group (25.59±7.36,2.63±4.98 and 80.60±25.06) 90 d after treatment (P＜0.05).No significant differences in blood biochemical indicators were noted between therapy group and control group (P＞0.05).Conclusion Treatment with vinpoccetine in patients with acute cerebral infarction is effective.
