Morphological changes of brain gray matter structure in patients with Parkinson's disease
10.3760/cma.j.issn.1671-8925.2014.02.008
- VernacularTitle:帕金森病患者的脑灰质形态学改变
- Author:
Weizhong TIAN
1
;
Ying LIU
;
Huaming JI
;
Ji ZHANG
;
Xiaohui SHENG
;
Jinli ZHAO
;
Jianguo XIA
Author Information
1. 南通大学附属泰州市人民医院影像科
- Keywords:
Parkinson's disease;
Mild cognitive impairment;
Voxel-based morphometry;
Gray abnormity
- From:
Chinese Journal of Neuromedicine
2014;13(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormal region of gray matter and its' structural changes closely related to mild cognitive impairment in patients with Parkinson's disease (PD) using voxel-based morphometry(VBM) method.Methods Thirty-seven clinically defined PD patients and 20 normal controls (NC),collected in our hospital from March 2011 to February 2013,were examined using T1WI three-dimensional brain volume sequence (3D-fast spoiled gradient echo,3D-FSPGR).We classified PD patients into 2 subgroups according to the extent of cognitive impairment:20 patients with mild cognitive impairment (MCI) and 17 patients with none mild cognitive impairment (nMCI).The data of three groups were analyzed using VBM based on SPM5 to generate gray matter map.Results As compared with NC group,PD patients showed extensively decreased gray matter volume,involving bilateral frontal,temporal,occipital and parietal lobes,insular,parahippocampal gyrus,amygdale and right uncus.As compared with PD-nMCI patients,decreased gray matter volume in PD-MCI patients was observed in bilateral midfrontal gyrus,inferior frontal gyrus,bilateral insular,left precentral gyrus,left superior temporal gyrus and right midtemporal gyrus.Conclusions Areas of decreased gray volume in PD patients locate in widespread brain regions involving limbic system and neocortex.Gray matter atrophy in bilateral midfrontal gyrus,inferior frontal gyrus,insular and left precentral gyrus is related to the mild cognitive impairment.
