Functional anatomy of the brain in depression patients with cognitive dysfunction based on functional magnetic resonance imaging
10.3760/cma.j.issn.1671-8925.2014.02.007
- VernacularTitle:基于功能磁共振技术对抑郁症患者认知功能损害的脑功能解剖学研究
- Author:
Jun LI
1
;
Lijie REN
;
Manfu HAN
;
Zhuqing ZHOU
;
Yuezhi LI
Author Information
1. 518036 深圳,安徽医科大学深圳二院临床学院,深圳市第二人民医院神经内科
- Keywords:
Depression;
Cognitive function;
Dffusion tnsor imaging
- From:
Chinese Journal of Neuromedicine
2014;13(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of functional anatomy of the brain in depression patients with cognitive dysfunction and its pathological basis.Methods Twenty-four patients with first episode of depression,admitted to our hospital from May 2008 to December 2009,and 24 healthy controls,collected at the same time period,were chosen in our study; they were all assessed by Hamilton depression (HAMD) scale and Wisconsin test; fractional anisotropy (FA) values of the various parts of white matter were measured by diffusion tensor imaging (DTI),and functional MRI was performed when the testers were conducting N-back task; the related indicators and imaging results were statistically analyzed.Results The brain areas in the depression group having significant difference as compared with those in the healthy controls (P＜0.05) included the bilateral frontal lobes (the leg bilateral frontal lobe,t=-5.884; the right bilateral frontal lobe,t=-4.517),anterior cingulate cortex (t=-14.402) and corpus callosum (t=-3.701).In patients of depression group,the left frontal FA values were negatively correlated with the disease duration (r=-0.555),and FA values of left bilateral frontal lobe and anterior cingulate cortex were negatively correlated to perseverative responses errors (Rpe) and mean response times (mRT,P＜0.05); the disease duration was positively correlated to Rpe and mRT (P＜0.05).The activating reduced brain areas of the depression group when they were conducting N-back task included bilateral frontal gyrus,left middle frontal gyrus,inferior fiontal gyrus and superior parietal lobule.Conclusion The depression patients have significant cognitive impairment; the damage of frontal white matter fiber and abnormalities of gray matter may be the pathological basis.
