Levels of platelet-leukocyte aggregates in patients with delayed encephalopathy after acute carbon monoxide poisoning
10.3760/cma.j.issn.1671-8925.2014.01.018
- VernacularTitle:急性一氧化碳中毒迟发脑病外周血血小板-白细胞聚集体水平研究
- Author:
Ankui JIA
1
;
Yanxuan LIU
;
Sibei JI
;
Guolin ZHANG
;
Hua ZHONG
;
Guangxia XU
Author Information
1. 新乡医学院第一附属医院检验科
- Keywords:
Delayed encephalopathy in acute carbon monoxide poisoning;
Aacute carbon monoxide poisoning;
Platelet-leukocyte aggregates
- From:
Chinese Journal of Neuromedicine
2014;13(1):80-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the circulating levels of platelet-leukocyte aggregates (PLA) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods The circulating levels of platelet-neutrophil aggregates (PNA) and platelet-monocyte aggregates (PMA) were quantified in 30 patients with DEACMP (DEACMP group) and 30 patients with acute carbon monoxide poisoning (ACOP group) by using flow cytometry assay,whose results were compared with those of 20 healthy subjects (controls).Results Circulating PNA and PMA levels in DEACMP group and ACOP group at acute stage were significantly higher than those in controls,respectively (P＜0.05),while no significant difference was noted between ACOP group and DEACMP group at acute stage (P＞0.05),indicating that platelets were in activation status and PLA levels raised significantly in patients with DEACMP and ACOP at acute stage.Circulating PNA and PMA levels were significantly higher in DEACMP group at acute stage than those in DEACMP group at stable stage (P＜ 0.05),suggesting that platelet activation were controlled after the illness state were stabilized in patients with DEACMP.Conclusion Platelet is involved in the pathogenesis of DEACMP and the change trend of circulating PLA levels is basically consistent with illness state.
