Chronic hippocampus electrical stimulation for treatment of patients with temporal lobe epilepsy
10.3760/cma.j.issn.1671-8925.2012.12.004
- VernacularTitle:慢性海马电刺激治疗颞叶癫痫二例报告
- Author:
Tao YU
1
;
Guo-Jun ZHANG
;
Dong-Sheng XIAO
;
Yuan-Yuan PIAO
;
Wei DU
;
Yong-Jie LI
Author Information
1. 100053北京,首都医科大学宣武医院神经外科,北京功能神经外科研究所,脑功能疾病调控治疗北京市重点实验室
- Keywords:
Hippocampus electrical stimulation;
Temporal lobe epilepsy;
Surgery
- From:
Chinese Journal of Neuromedicine
2013;12(12):1201-1204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness and safety of chronic hippocampus electrical stimulation in treatment of patients with temporal lobe epilepsy.Methods The patients with temporal lobe epilepsy who were not suitable for anterior temporal lobectomy were selected.The patients had a 6-month-seizure count as baseline frequency.Medtronic electrodes were implanted directed into the amygdalohippocampal foci.After electroencephalography recording and interval stimulation for one week,implantable pulse generators were implanted and began to stimulate chronically.Seizure frequency was counted in the follow up.The efficacy and side-effect were also detected.Results Two patients were selected according to the criteria.There was no obvious side effect except for transient dizziness in one patient.One patient had a seizure reduction of＞80％ in a 22-month follow-up (decreasing from 3-4 times/month to 2-3 times/month); the seizure time was shorten and severity was alleviated than before treatment The other patient had a seizure reduction of＞50％ in a 10-month follow-up (decreasing from 6-10 times/month to 3-6 times/month); the seizure time was shorten than before treatment with few secondary generalized tonic-clonic seizures.Conclusion Chronic hippocampus electrical stimulation is a safe treatment for some patients with temporal lobe epilepsy who are not suitable for anterior temporal lobectomy; it may be helpful in controlling the seizures.
