Relationship between depression after ischemic stroke and leukoaraiosis
10.3760/cma.j.issn.1671-8925.2013.10.016
- VernacularTitle:缺血性脑卒中后抑郁与脑白质疏松关系的初步研究
- Author:
Jun-Feng QIAN
1
;
Zhi-Jun ZHANG
;
Fang-Yuan QIAN
;
Ling-Li YANG
;
Jun-Xiang LUAN
Author Information
1. 东南大学附属中大医院神经内科
- Keywords:
Post-stroke depression;
Leukoaraiosis;
Age-related white matter change;
Deep white matter hyperintensity
- From:
Chinese Journal of Neuromedicine
2013;12(10):1043-1049
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between post-stroke depression (PSD) and leukoaraiosis in a well-defined acute ischemic stroke cohort.Methods One hundred and sixty-eight patients with acute ischemic stroke,admitted to our hospital from June 2007 to March 2011,were examined by magnetic resonance imaging.The patients were made a diagnosis of post-stroke depression by the Diagnostic and Statistical Manual for Mental Disorders,Fourth Edition (DSM-IV) criteria 2 weeks after the index stroke; 60 (35.7％) patients had PSD in the acute period and 60 stroke patients without depression matched according to age and gender served as a control group were chosen.The distribution and severity of leukoaraiosis were evaluated using scale developed by Fazekas and age-related white matter changes (ARWMC) scale.The risk factors of PSD were chosen after univariate analysis and multivariate logistic regression analysis.Results In comparison with the non-PSD group,patients in the PSD group were more likely to have high deep white matter hyperintensities (DWMHs) scores and ARWMC scale scores in the frontal area with significant difference (P＜0.05).There were no significant differences in periventricular white matter hypertensities (PVWMHs) scores and ARWMC scale scores in the parieto-occipital area,temporal area,infratentorial area and basal ganglia area between the PSD and control groups (P＞0.05).In the multivariate logistic regression analysis,DWMHs remained an independent risk factor of PSD (OR:1.740,95％CI:1.194-2.536,P=0.004).Conclusion There may be an association between PSD and leukoaraiosis; severe leukoaraiosis in the deep area may increase vulnerability to develop depression in the acute period after ischemic stroke.
